@article{10.11648/j.ijidt.20251003.12,
  author = {Tahani Momotaz and Rehana Razzak Khan and Fatima Afroz and Abu Naser Ibne Sattar},
  title = {Vancomycin Resistant Enterococci in a Tertiary Care Hospital of Dhaka, Bangladesh
},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {10},
  number = {3},
  pages = {62-67},
  doi = {10.11648/j.ijidt.20251003.12},
  url = {https://doi.org/10.11648/j.ijidt.20251003.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20251003.12},
  abstract = {Vancomycin resistant Enterococci (VRE) are multidrug resistant emerging pathogens that can cause various hospital and community acquired infections with increased mortality and morbidity. VRE is now becoming a global threat due to limited treatment options. So, this cross-sectional study was undertaken to detect VRE in a tertiary care hospital of Bangladesh by both phenotypic and genotypic method. A total of 87 Enterococcus spp. isolated from different clinical samples in the laboratory of Department of Microbiology and Immunology of Bangladesh Medical University (BMU) were studied from March 2019-February 2020. Enterococci of this study comprises E. faecalis (65), E. faecium (20) and E. raffinosus (2). According to this study, 67.8%, 60.9%, 56.3%, 47.1% and 43.7% of Enterococci were resistant to ciprofloxacin, gentamicin, nitrofurantoin, ampicillin and cotrimoxazole respectively. VRE was detected phenotypically by determination of minimal inhibitory concentration (MIC) of vancomycin by agar dilution method and genotypically by detection of vanA and vanB gene by conventional PCR. The prevalence of VRE was 3.4% (3 out of 87). The highest MIC value of vancomycin 256 μg/ml and 128 μg/ml was observed in two and one VRE isolates respectively. The vanA gene was detected in all VRE isolates. Two (66.67%) VRE were isolated from urine and 1 (33.33%) from blood sample. All VRE isolates were E. faecium and only susceptible to Linezolid and Fosfomycin. Detection of VRE in this study place warrants strict infection control and prevention policy to combat this difficulty to treat pathogen. It also provides important data regarding susceptibility of Enterococcus spp. and VRE.
},
 year = {2025}
}

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TY  - JOUR
T1  - Vancomycin Resistant Enterococci in a Tertiary Care Hospital of Dhaka, Bangladesh

AU  - Tahani Momotaz
AU  - Rehana Razzak Khan
AU  - Fatima Afroz
AU  - Abu Naser Ibne Sattar
Y1  - 2025/10/30
PY  - 2025
N1  - https://doi.org/10.11648/j.ijidt.20251003.12
DO  - 10.11648/j.ijidt.20251003.12
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 62
EP  - 67
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20251003.12
AB  - Vancomycin resistant Enterococci (VRE) are multidrug resistant emerging pathogens that can cause various hospital and community acquired infections with increased mortality and morbidity. VRE is now becoming a global threat due to limited treatment options. So, this cross-sectional study was undertaken to detect VRE in a tertiary care hospital of Bangladesh by both phenotypic and genotypic method. A total of 87 Enterococcus spp. isolated from different clinical samples in the laboratory of Department of Microbiology and Immunology of Bangladesh Medical University (BMU) were studied from March 2019-February 2020. Enterococci of this study comprises E. faecalis (65), E. faecium (20) and E. raffinosus (2). According to this study, 67.8%, 60.9%, 56.3%, 47.1% and 43.7% of Enterococci were resistant to ciprofloxacin, gentamicin, nitrofurantoin, ampicillin and cotrimoxazole respectively. VRE was detected phenotypically by determination of minimal inhibitory concentration (MIC) of vancomycin by agar dilution method and genotypically by detection of vanA and vanB gene by conventional PCR. The prevalence of VRE was 3.4% (3 out of 87). The highest MIC value of vancomycin 256 μg/ml and 128 μg/ml was observed in two and one VRE isolates respectively. The vanA gene was detected in all VRE isolates. Two (66.67%) VRE were isolated from urine and 1 (33.33%) from blood sample. All VRE isolates were E. faecium and only susceptible to Linezolid and Fosfomycin. Detection of VRE in this study place warrants strict infection control and prevention policy to combat this difficulty to treat pathogen. It also provides important data regarding susceptibility of Enterococcus spp. and VRE.

VL  - 10
IS  - 3
ER  - 

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